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KMID : 0525720190240040239
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Journal of Chitin and Chitosan
2019 Volume.24 No. 4 p.239 ~ p.245
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Protective Effect of UV-induced Arthrospira Platensis (Spirulina) Mutant on UV-B Irradiated Human Dermal Fibroblasts Injury
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Ha Sang-Keun
Lee Jae-Hwa
Lee Sang-Hoon
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Abstract
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In this study, we investigated the protective effect of UV-induced Arthrospira platensis (Spirulina) mutant and its possible mechanisms on UV-B irradiated human dermal fibroblasts (HDFs) injury. Ultraviolet rays were irradiated in order to induce the mutation of A. platensis and 5 strains were selected with respect to better growth. Among the 5 extracts of A. platensis mutants, UV1-2 mutant extract showed significant increase of type I procollagen synthesis and inhibition of MMP-1 expression. Transcription factors NF-κB and AP-1 were downregulated by UV1-2 in a dose-dependent manner. Moreover, UV1-2 mutant extract blocked MAPKs pathway, which is upstream signalling of NF-κB activation. This study suggests that UV1-2 mutant extract can be used as a therapeutic agent to prevent UV-B induced skin photoaging.
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KEYWORD
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Microalgae, Mutation, Skin aging, MMP-1, Collagen synthesis
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